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The perform of SIK1 in tumorigenesis. SIK1 is often a tumor suppressor gene, which performs a vital regulatory part in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and affects cancer mobile proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 may endorse most cancers mobi